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Interdisciplinary NanoBioSciences Lab
The University of Mississippi

2020

Werfel T. A., Hicks D. J., Rahman B., Bindeman W., Duvernay M., Maeng J., Hamm H., Lavieri R., Morrison Joly M., Pulley J., Elion D., Brantley-Sieders D., Cook R. S. Repurposing of a Thromboxane Receptor Inhibitor Based on a Novel Role in Metastasis Identified by Phenome Wide Association Study. Molecular Cancer Therapeutics. 2020, 19(12), 2454-2464. Full Text

Shofolawe-Bakare O. T., Stokes L. D., Hossain M., Smith A. E., Werfel T. A. Immunostimulatory Biomaterials to Boost Tumor Immunogenicity. Biomaterials Science. 2020, 8, 5516-5537. *2021 Emerging Investigators Special Edition. Full Text

Boire T. C., Himmel L. E., Yu F., Guth C., Dollinger B. R., Werfel T. A., Balikov D. A., Cheung-Flynn J., Duvall C. L. Effect of Pore Size and Spacing on Neovascularization of a Biodegradable Shape Memory Polymer Perivascular Wrap. Journal of Biomedical Materials Research: Part A. 2020, 1-17. Full Text

2019

Vanderburgh J. P.*, Kwakwa K. A.*, Werfel T. A., Merkel A. R., Gupta M. K., Johnson R. W., Guelcher S. A., Duvall C. L., Rhoades(Sterling) J. A. Systemic delivery of a Gli inhibitor via polymeric nanocarriers inhibits tumor-induced bone disease. Journal of Controlled Release. 2019, 311/312, 257-272. *Co-first authors. Full Text

Hendershot J., Smith A. E., Werfel T. A. Preparation of neutrally-charged, pH-responsive nanoparticles for cytosolic siRNA delivery. J. Vis. Exp. (147), e59549, 2019, doi:10.3791/59549. Full Text

Kilchrist K. V., Dimobi S. D., Jackson M. A., Evans B. C., Werfel T. A., Dailing E. A., Bedingfield S. K., Kelly I. B., Duvall C. L. Gal8 Visualization of Endosome Disruption Predicts Carrier-Mediated Biologic Drug Intracellular Bioavailability. ACS Nano. 2019, 10.1021/acsnano.8b05482. Full Text

Werfel T. A., Elion D. L., Rahman B., Hicks D. J., Sanchez V. M., Gonzalez Ericsson P., Nixon M. J., James J., Balko J. M., Scherle P. A., Koblish K., Cook R. S. Treatment-induced tumor cell apoptosis and secondary necrosis drive tumor progression in the residual tumor microenvironment through MerTK and IDO-1. Cancer Research. 2019, 10.1158/0008-5472.CAN-18-1106. Full Text

2018

Werfel T. A., Cook R. S. Efferocytosis in the tumor microenvironment. Seminars in Immunopathology. 2018, https://doi.org/10.1007/s00281-018-0698-5. Full Text

Werfel T. A., Wang S., Jackson M. A., Kavanaugh T. E., Morrison Joly M., Lee L., Hicks D. J., Sanchez V. M., Gonzalez Ericsson P., Kilchrist K. V., Dimobi S. C., Sarett S. M., Brantley-Sieders D. M., Cook R. S., Duvall C. L. Selective mTORC2 inhibitor therapeutically blocks breast cancer cell growth and survival. Cancer Research. 2018, 78(7), 1845-1858. Full Text

Williams M. M., Lee L., Werfel T. A., Joly M. M., Hicks D. J., McKernan C., Sanchez V. M., Estrada M. V., Massarweh S., Elledge R., Duvall C. L., Cook R. S. Intrinsic Apoptotic Pathway Activation Increases Response to Anti-Estrogens in Luminal Breast Cancers. Cell Death and Disease. 2018, 9(21). Full Text

2017

Sarett S. M., Werfel T. A., Lee L., Jackson M. A., Kilchrist K. V., Brantley-Sieders D. M., Duvall C. L. Lipophilic siRNA Targets Albumin In Situ and Promotes Bioavailability, Tumor Penetration, and Carrier-free Gene Silencing. Proceedings of the National Academy of Sciences. 2017, 114(32), 6490-6497. Full Text

Jackson M. A., Werfel T. A., Curvino E. J., Yu F., Kavanaugh T. E., Sarett S. M., Dockery M. D., Kilchrist K. V., Jackson A. N., Giorgio T. D., Duvall C. L. Zwitterionic Nanocarrier Surface Chemistry Improves siRNA Tumor Delivery and Silencing Activity Relative to Polyethylene Glycol. ACS Nano. 2017, 11(6), 5680-5696. Full Text

Werfel T. A., Jackson M. A., Kavanaugh T. E., Kirkbride K. C., Miteva M., Giorgio T. D., Duvall C. L. Combinatorial Optimization of PEG Architecture and Hydrophobic Content Improves Ternary siRNA Polyplex Stability, Pharmacokinetics, and Potency In Vivo. Journal of Controlled Release. 2017, 255, 12-26. Full Text

2016

Beavers K. R., Werfel T. A., Shen T., Kavanaugh T. E., Kilchrist K. V., Mares J. W., Fain J. S., Wiese C. B., Vickers K. C., Weiss S. M, Duvall C. L. Porous Silicon and Polymer Nanocomposites for Delivery of Peptide Nucleic Acid Anti-microRNA Therapeutics. Advanced Materials. 2016, 28: 7984–7992. Full Text

Sarett S. M.*, Werfel T. A.*, Chandra I., Jackson M. A., Kavanaugh T. E., Hattaway M. E., Giorgio T. D., Duvall C. L. Hydrophobic Interactions between Polymeric Carrier and Palmitic Acid-Conjugated siRNA Improve PEGylated Polyplex Stability and Enhance In Vivo Pharmacokinetics and Tumor Gene Silencing. Biomaterials. 2016, 97, 122-132. *Co-first authors. Full Text

Uddin M. J.*, Werfel T. A.*, Crews B. C., Gupta M. K., Kavanaugh T. E., Kingsley P. J., Boyd K., Marnett L. J., Duvall C. L. Fluorocoxib A Loaded Nanoparticles Enable Targeted Visualization of Cyclooxygenase-2 in Inflammation and Cancer. Biomaterials. 2016, 92, 71-80. *Co-first authors. Full Text

Werfel T. A., Swain C., Nelson C. E., Kilchrist K. V., Evans B. C., Miteva M., Duvall C. L. Hydrolytic Charge-reversal of PEGylated Polyplexes Enhanced Intracellular Un-packaging and Activity of siRNA. Journal of Biomedical Materials Research: Part A. 2016, 104, 917-927. Full Text

2015

Kavanaugh T. E., Werfel T. A., Cho H., Hasty K. A., Duvall C. L. Particle-based technologies for osteoarthritis detection and therapy. Drug Delivery and Translational Research. 2015, 10.1007/s133346-015-0234-2. Full Text

Miteva M., Kirkbride K. C., Kilchrist K. V., Werfel T. A., Li H., Nelson C. E., Gupta M. K., Giorgio T. D., Duvall C. L. Tuning PEGylation of mixed micelles to overcome intracellular and systemic siRNA delivery barriers. Biomaterials. 2015, 38, 97 – 107. Full Text

2014

Eichaker L. R., Cho H., Duvall C. L., Werfel T. A., Hasty K. A. Future nanomedicine for the diagnosis and treatment of osteoarthritis. Nanomedicine (Lond). 2014, 9, 2203 – 2215. Full Text

Gupta M. K., Martin J. R., Werfel T. A., Shen T., Page J. M., Duvall C. L. Cell Protective, ABC Triblock Polymer-Based Thermoresponsive Hydrogels with ROS-Triggered Degradation and Drug Release. Journal of the American Chemical Society. 2014, 136, 14896 – 14902. Full Text

Adolph E. J., Nelson C. E., Werfel T. A., Guo R., Davidson J. M., Guelcher S. A., Duvall C. L. Enhanced performance of plasmid DNA polyplexes stabilized by a combination of core hydrophobicity and surface PEGylation. Journal of Materials Chemistry B. 2014, 2, 8154 – 8164. Full Text

2013

Li H., Yu S. S., Miteva M., Nelson C. E., Werfel T. A., Giorgio T. D., Duvall C. L. Matrix Metalloproteinase Responsive, Proximity-Activated Polymeric Nanoparticles for siRNA Delivery. Advanced Functional Materials. 2013, 23, 3040 – 3052. Full Text

 

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