2024
Mohammad S. A., Toragall V. B., Fortenberry A. W., Shofolawe-Bakare O. T., Sulochana S., Heath K. E., Owolabi I., Tassin G., Flynt A. S., Smith A. E., Werfel T. A. Postpolymerization Modification of Poly(2-vinyl-4,4-dimethyl azlactone) as a Versatile Strategy for Drug Conjugation and Stimuli-Responsive Release. Biomacromolecules. 2024. 25, 4, 2621-2634. Full Text
Amarasekara D. L., Kariyawasam C. S., Hejny M. A., Toragall V. B., Werfel T. A., Fitzkee N. C. Protein-Functionalized Gold Nanospheres with Tunable Photothermal Efficiency for the Near-Infrared Photothermal Ablation of Biofilms. ACS Applied Materials and Interfaces. 2024. 16, 4, 4321-4332. Full Text
2023
Toragall V. B., Hale E. J., Hulugalla K. R., Werfel T. A. Microscopy and Plate Reader-based Methods for Monitoring the Interaction of Platelets and Tumor Cells in vitro. Bio-protocol. 2023. 13(20). Full Text
Brewster P. R., Ishraq Bari S. M., Walker G. M., Werfel T. A. Current and Future Directions of Drug Delivery for the Treatment of Mental Illnesses. Advanced Drug Delivery Reviews. 2023. 114824. Full Text
Hossain M., Sulochana S. P., Heath K. E., Ishraq Bari S. M., Brewster P., Barnes J., Munivar A., Walker G. M., Puleo D. A., Werfel T. A. Interval Delivery of 5HT2A Agonists Using Multilayered Polymer Films. Journal of Biomedical Materials Research Part A. 2023. 10.1002/jbm.a.37497. Full Text
2022
De Mel J., Hossain M., Shofolawe-Bakare O. T., Mohammad S. K., Rasmussen E., Milloy K., Shields M., Roth E. W., Arora K., Cueto R., Tang S., Wilson J. T., Smith A. E., Werfel T. A. Dual-Responsive Glycopolymers for Intracellular Codelivery of Antigen and Lipophilic Adjuvants. Molecular Pharmaceutics. 2022, 19(12), 4705-4716. Full Text
Shofolawe-Bakare O. T., De Mel J. U., Mishra S. K., Hossain M., Hamadani C. M., Pride M. C., Dasanayake G. S., Monroe W., Roth E. W., Tanner E. E. L., Doerksen R. J., Smith A. E., Werfel T. A. ROS-Responsive Glycopolymeric Nanoparticles for Enhanced Drug Delivery to Macrophages. Macromolecular Bioscience. 2022. 2200281. Full Text
Fortenberry A. W., Mohammad S. A., Werfel T. A., Smith A. E. Comparative Investigation of the Hydrolysis of Charge-Shifting Polymers Derived from an Azlactone-Based Polymer. Macromolecular Rapid Communications. 2022. 2200420. Full Text
Werfel T. A. Assessment of the Immune Response to Tumor Cell Apoptosis and Efferocytosis. Apoptosis and Cancer (Methods in Molecular Biology). 2022. 45-55. Full Text
Hamadani C. M., Chandrasiri I., Yaddehige M. L., Dasanayake G. S., Owolabi I., Flynt A., Hossain M., Liberman L., Lodge T. P., Werfel T. A., Watkins D. L., Tanner E. E. L. Improved Nanoformulation and Bio-Functionalization of Linear-Dendritic Block Copolymers with Biocompatible Ionic Liquids. Nanoscale. 2022, 14(16), 6021-6036. Full Text
2021
Boire T. C., Himmel L. E., Yu F., Guth C., Dollinger B. R., Werfel T. A., Balikov D. A., Cheung-Flynn J., Duvall C. L. Effect of Pore Size and Spacing on Neovascularization of a Biodegradable Shape Memory Polymer Perivascular Wrap. Journal of Biomedical Materials Research: Part A. 2021, 109 (3), 272-288. Full Text
2020
Werfel T. A., Hicks D. J., Rahman B., Bindeman W., Duvernay M., Maeng J., Hamm H., Lavieri R., Morrison Joly M., Pulley J., Elion D., Brantley-Sieders D., Cook R. S. Repurposing of a Thromboxane Receptor Inhibitor Based on a Novel Role in Metastasis Identified by Phenome Wide Association Study. Molecular Cancer Therapeutics. 2020, 19(12), 2454-2464. Full Text
Shofolawe-Bakare O. T., Stokes L. D., Hossain M., Smith A. E., Werfel T. A. Immunostimulatory Biomaterials to Boost Tumor Immunogenicity. Biomaterials Science. 2020, 8, 5516-5537. *2021 Emerging Investigators Special Edition. Full Text
2019
Vanderburgh J. P.*, Kwakwa K. A.*, Werfel T. A., Merkel A. R., Gupta M. K., Johnson R. W., Guelcher S. A., Duvall C. L., Rhoades(Sterling) J. A. Systemic delivery of a Gli inhibitor via polymeric nanocarriers inhibits tumor-induced bone disease. Journal of Controlled Release. 2019, 311/312, 257-272. *Co-first authors. Full Text
Hendershot J., Smith A. E., Werfel T. A. Preparation of neutrally-charged, pH-responsive nanoparticles for cytosolic siRNA delivery. J. Vis. Exp. (147), e59549, 2019, doi:10.3791/59549. Full Text
Kilchrist K. V., Dimobi S. D., Jackson M. A., Evans B. C., Werfel T. A., Dailing E. A., Bedingfield S. K., Kelly I. B., Duvall C. L. Gal8 Visualization of Endosome Disruption Predicts Carrier-Mediated Biologic Drug Intracellular Bioavailability. ACS Nano. 2019, 10.1021/acsnano.8b05482. Full Text
Werfel T. A., Elion D. L., Rahman B., Hicks D. J., Sanchez V. M., Gonzalez Ericsson P., Nixon M. J., James J., Balko J. M., Scherle P. A., Koblish K., Cook R. S. Treatment-induced tumor cell apoptosis and secondary necrosis drive tumor progression in the residual tumor microenvironment through MerTK and IDO-1. Cancer Research. 2019, 10.1158/0008-5472.CAN-18-1106. Full Text
2018
Werfel T. A., Cook R. S. Efferocytosis in the tumor microenvironment. Seminars in Immunopathology. 2018, https://doi.org/10.1007/s00281-018-0698-5. Full Text
Werfel T. A., Wang S., Jackson M. A., Kavanaugh T. E., Morrison Joly M., Lee L., Hicks D. J., Sanchez V. M., Gonzalez Ericsson P., Kilchrist K. V., Dimobi S. C., Sarett S. M., Brantley-Sieders D. M., Cook R. S., Duvall C. L. Selective mTORC2 inhibitor therapeutically blocks breast cancer cell growth and survival. Cancer Research. 2018, 78(7), 1845-1858. Full Text
Williams M. M., Lee L., Werfel T. A., Joly M. M., Hicks D. J., McKernan C., Sanchez V. M., Estrada M. V., Massarweh S., Elledge R., Duvall C. L., Cook R. S. Intrinsic Apoptotic Pathway Activation Increases Response to Anti-Estrogens in Luminal Breast Cancers. Cell Death and Disease. 2018, 9(21). Full Text
2017
Sarett S. M., Werfel T. A., Lee L., Jackson M. A., Kilchrist K. V., Brantley-Sieders D. M., Duvall C. L. Lipophilic siRNA Targets Albumin In Situ and Promotes Bioavailability, Tumor Penetration, and Carrier-free Gene Silencing. Proceedings of the National Academy of Sciences. 2017, 114(32), 6490-6497. Full Text
Jackson M. A., Werfel T. A., Curvino E. J., Yu F., Kavanaugh T. E., Sarett S. M., Dockery M. D., Kilchrist K. V., Jackson A. N., Giorgio T. D., Duvall C. L. Zwitterionic Nanocarrier Surface Chemistry Improves siRNA Tumor Delivery and Silencing Activity Relative to Polyethylene Glycol. ACS Nano. 2017, 11(6), 5680-5696. Full Text
Werfel T. A., Jackson M. A., Kavanaugh T. E., Kirkbride K. C., Miteva M., Giorgio T. D., Duvall C. L. Combinatorial Optimization of PEG Architecture and Hydrophobic Content Improves Ternary siRNA Polyplex Stability, Pharmacokinetics, and Potency In Vivo. Journal of Controlled Release. 2017, 255, 12-26. Full Text
2016
Beavers K. R., Werfel T. A., Shen T., Kavanaugh T. E., Kilchrist K. V., Mares J. W., Fain J. S., Wiese C. B., Vickers K. C., Weiss S. M, Duvall C. L. Porous Silicon and Polymer Nanocomposites for Delivery of Peptide Nucleic Acid Anti-microRNA Therapeutics. Advanced Materials. 2016, 28: 7984–7992. Full Text
Sarett S. M.*, Werfel T. A.*, Chandra I., Jackson M. A., Kavanaugh T. E., Hattaway M. E., Giorgio T. D., Duvall C. L. Hydrophobic Interactions between Polymeric Carrier and Palmitic Acid-Conjugated siRNA Improve PEGylated Polyplex Stability and Enhance In Vivo Pharmacokinetics and Tumor Gene Silencing. Biomaterials. 2016, 97, 122-132. *Co-first authors. Full Text
Uddin M. J.*, Werfel T. A.*, Crews B. C., Gupta M. K., Kavanaugh T. E., Kingsley P. J., Boyd K., Marnett L. J., Duvall C. L. Fluorocoxib A Loaded Nanoparticles Enable Targeted Visualization of Cyclooxygenase-2 in Inflammation and Cancer. Biomaterials. 2016, 92, 71-80. *Co-first authors. Full Text
Werfel T. A., Swain C., Nelson C. E., Kilchrist K. V., Evans B. C., Miteva M., Duvall C. L. Hydrolytic Charge-reversal of PEGylated Polyplexes Enhanced Intracellular Un-packaging and Activity of siRNA. Journal of Biomedical Materials Research: Part A. 2016, 104, 917-927. Full Text
2015
Kavanaugh T. E., Werfel T. A., Cho H., Hasty K. A., Duvall C. L. Particle-based technologies for osteoarthritis detection and therapy. Drug Delivery and Translational Research. 2015, 10.1007/s133346-015-0234-2. Full Text
Miteva M., Kirkbride K. C., Kilchrist K. V., Werfel T. A., Li H., Nelson C. E., Gupta M. K., Giorgio T. D., Duvall C. L. Tuning PEGylation of mixed micelles to overcome intracellular and systemic siRNA delivery barriers. Biomaterials. 2015, 38, 97 – 107. Full Text
2014
Eichaker L. R., Cho H., Duvall C. L., Werfel T. A., Hasty K. A. Future nanomedicine for the diagnosis and treatment of osteoarthritis. Nanomedicine (Lond). 2014, 9, 2203 – 2215. Full Text
Gupta M. K., Martin J. R., Werfel T. A., Shen T., Page J. M., Duvall C. L. Cell Protective, ABC Triblock Polymer-Based Thermoresponsive Hydrogels with ROS-Triggered Degradation and Drug Release. Journal of the American Chemical Society. 2014, 136, 14896 – 14902. Full Text
Adolph E. J., Nelson C. E., Werfel T. A., Guo R., Davidson J. M., Guelcher S. A., Duvall C. L. Enhanced performance of plasmid DNA polyplexes stabilized by a combination of core hydrophobicity and surface PEGylation. Journal of Materials Chemistry B. 2014, 2, 8154 – 8164. Full Text
2013
Li H., Yu S. S., Miteva M., Nelson C. E., Werfel T. A., Giorgio T. D., Duvall C. L. Matrix Metalloproteinase Responsive, Proximity-Activated Polymeric Nanoparticles for siRNA Delivery. Advanced Functional Materials. 2013, 23, 3040 – 3052. Full Text